The G20210A Prothrombin Mutation and the Physicians’ Health Study
نویسندگان
چکیده
منابع مشابه
Prothrombin gene mutation (G20210A) in healthy Centenarians.
A recently described genetic variant of the prothrombin gene (G to A transition at nucleotide position 20210) is associated with an increased risk of venous thrombosis (1). The 20210A prothrombin allele may precipitate cerebral ischemia or myocardial infarction in young patients with known prothrombotic abnormalities (2, 3). Similarly, it has been demonstrated that factor V Leiden further incre...
متن کاملEpidemiology of Prothrombin G20210A Mutation in the Mediterranean Region
There are many genetic and acquired risk factors that are known to cause venous thromboembolic disorders (VTE). One of these is the Prothrombin G20210A mutation, which has been identified in 1996. Prothrombin G20210A mutation causes higher levels of the clotting factor prothrombin in the blood of carriers, which creates a higher tendency towards blood clotting (hypercoagulability), and therefor...
متن کاملMultisite study for genotyping of the factor II (prothrombin) G20210A mutation by the invader assay.
References 1. Sunderman FW. The clinical biochemistry of 59-nucleotidase [Review]. Ann Clin Lab Sci 1990;20:123–39. 2. Bodansky O, Schwartz MK. 59-Nucleotidase [Review]. Adv Clin Chem 1968; 11:277–328. 3. Dixon TF, Purdom M. Serum 59-nucleotidase. J Clin Pathol 1954;7:341–3. 4. Eshchar J, Rudzki C, Zimmerman HJ. Serum levels of 59-nucleotidase in disease. Am J Clin Pathol 1967;47:598–606. 5. Be...
متن کاملFactor V Leiden, MTHFR C677T and Prothrombin Gene Mutation G20210A in Iranian Patients with Venous Thrombosis
Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. Methods: This study was carried out...
متن کاملProthrombin Mutation G20210A as a Cause of Budd-Chiari Syndrome
characterized by thrombus formation in the hepatic vein.1 Untreated, prognosis is generally poor. The main interventions are construction of an operative shunt and orthotopic liver transplantation.2 The prothrombin 20210 G to A mutation (G20210A) has been shown to cause spontaneous production of fibrin and an increased risk of thrombosis. This mutation may have caused cases of Budd-Chiari syndr...
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ژورنال
عنوان ژورنال: Circulation
سال: 2000
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.101.21.e207